The aims of this study were to evaluate the antioxidant and antidiabetic activities of leaves and stems of five selected traditional medicinal plants using diphenyl. The selected plant parts were subjected to solvent extraction and analyzed for their antidiabetic activity using in vitro assays such as. Various ether soluble fractions as well as insoluble fractions of dried onion powder show antihyperglycemic activity in diabetic rabbits. Medicinal plants with potential antidiabetic activity and. Electrochemical measurement of antidiabetic potential of medicinal plants current nanoscience, 2015, vol. More investigations must be carried out to evaluate the exact mechanism of action of medicinal plants with antidiabetic and insulino mimetic activity. Antidiabetic potential of medicinal plants and their. African medicinal plants with antidiabetic potentials. However, their rates of type 2 diabetes mellitus t2dm, a disease that was unheard of in their midst 50 years ago, are the highest in the country. Mechanisms of action of indigenous antidiabetic plants from. Singab an, youssef fs, ashour ml 2014 medicinal plants with.
Pdf antidiabetic activity of selected medicinal plants. The medicinal plants produce antidiabetic activity due to presence of tannin, saponins, alkaloid, glycoside, polyphenol and flavonoids etc. If there is a longterm remedy for diabetes, it must lie in natures pharmacy of. International journal of pharmacognosy and phytochemical research 2014 15.
Mc and others published antidiabetic activity of selected medicinal plants and its possible mechanism of action find, read and cite all the research you need on. Antidiabetic agents from medicinal plants bentham science. Moreover, the cellular and metabolic effects involved in improving insulin sensitivity, the experiment model used in these studies and the. Medicinal plants with potential antidiabetic activity and their. View antidiabetic medicinal plants research papers on academia. The main thing controlling the synthesis and secretion of insulin is the concentration of glucose in blood. Antibacterial activity, antidiabetic plants, diabetes, medicinal plants, pathogenic bacteria, phenolics,staphylococcusaureus. Abstract plants provide a major resource for a large number of traditional medicines that have been in existence for thousands of years in. Evidence based antidiabetic selected indigenous medicinal. Therefore, extensive research has been directed toward the use of medicinal plants to control dm and its complications 9,10. It has been reported that there are 220 medicinal plant. Indigenous populations in canada possess a wealth of native traditional knowledge. In vitro investigation of antidiabetic potential of. In artemisia indica the hydromethanolic crude extract at a dose of 200 and 400 mgkg b.
Diabetes mellitus is a metabolic disorder which is rising globally in rich and developing countries. Vol6, issue 4, december 2014 january 2015, 856861 e 857 concentration of 0. A number of active components were isolated from medicinal plants for direct use as drugs, or act as a lead compound or pharmacological agents. Many indian medicinal plants are reported to be useful in diabetes mellitus and many species of genus artemisia have been reported to have antidiabetic activity. Plants have been a good source of medicine for the treatment of various type of disease, still many plants and active compounds obtained from plants have not been well characterized. Leucas inflata, marrubium vulgare, salvia schimper and origanum majorana.
Bhavani, 2014 antidiabetic activity of aegle marmelos international research journal of pharmaceutical and biosciences irjpbs 2014. Antidiabetic activity and phytochemical screening of. Acute toxic class method is a stepwise procedure with use of three animals of a single sex per step. It assists the researchers to understand mechanism of action, structure and potential antidiabetic activities of scientific evaluated plants. The use of medicinal plants for the management of diabetes. An overview and future scope on traditionally used herbal. Therefore, in the present study, five local traditional medicinal plants have been chosen for this purpose. Review on antidiabetic activity on medicinal plants. Flavonebased novel antidiabetic and antidyslipidemic agents. The results indicated that salvia schimperi essential oil exhibited the most dosedependent inhibitory activity against. The use of medicinal plants to manage diabetes is a prelude to a more realistic and more inclusive global health order. Folklore medicinal plants are mostly used for rural areas. Frontiers evaluation of antioxidant, antidiabetic and. Many plants have shown their immense potential to fight against dreadful diseases including cancer.
Hypoglycaemic activity of different extracts of various herbal plants. Medicinal plants as an alternative source of antidiabetic agents. Pdf medicinal plants with potential antidiabetic activity. In the african region this rate is the highest, with 20 million diagnosed diabetics. Despite a noticeable progress in the treatment of diabetes mellitus by synthetic drugs, the search for new natural antidiabetic agents is going on. Anti diabetic medicinal plants open access journals. An update 1mohd iqbal yatoo, 2archana saxena, 3arumugam gopalakrishnan, 4mahmoud alagawany and 5kuldeep dhama 1sherekashmir university of agricultural sciences and technology of kashmir, shalimar, 190025 srinagar. Medicinal plants have been proposed as rich yet unexploited potential sources for antidiabetic. Natural products, particularly of plant origin, are the main quarry for discovering promising lead candidates and play an imperative role in the upcoming drug development programs 24,25,26. Antidiabetic potential of medicinal plants and their active components. Plants have been the primary source of drugs and many of the currently available drugs have been directly or indirectly derived from plants.
Antidiabetic effect of compounds isolated from plants. Medicinal plants with potential antidiabetic activity a. Review on antidiabetic activity on medicinal plants scholar. Antiobesogenic and antidiabetic effects of plants and. It clearly shows the importance of medicinal plants in the treatment of diabetes mellitus. The optical enantiomers 70a, 70b, 90a, and 90b of two congeners 70 and 90 exhibiting consistent antidiabetic and antidyslipidemic activities were also prepared. Antidiabetic plants improving insulin sensitivity eddouks.
Antidiabetic medicinal plants gymnema sylvestre gymnema sylvestre has long been used as a treatment for diabetes 11. The hybrid congeners 6290 of 6 and 7hydroxyflavones with aminopropanol have been synthesized and evaluated for their antidiabetic activity in sucrosechallenged lowdosed streptozotocin stzinduced diabetic rats and dbdb mice. Important medicinal plants having antidiabetic potential allium cepa l. In vitro investigation of antidiabetic potential of selected.
Antidiabetic potential of some less commonly used plants. Potential antidiabetic activity of medicinal plants the journal of. An overview on antidiabetic medicinal plants having. Recently there has been some research works on the chemical composition, antioxidant and antimicrobial activities of essential oils of the four mentioned plants 1114. Determination of in vitro antidiabetic effects of zingiber officinale roscoe 603 glucose diffusion inhibition the potential of ginger rhizome extracts to inhibit glucose diffusion into the external solution was investi gated at set time intervals gallagher et al. In vitro antidiabetic activity of cardiospermum halicacabum leaves extracts by stalin. Significant reduction in glycaemia was observed only when ginseng was taken 40 min before gc in nondiabetic subjects and the same result was seen in diabetic subjects. Traditional medicines derived from medicinal plants are used by about 60% of the worlds population. Mechanisms of action of indigenous antidiabetic plants. Ease of availability, low cost, and least side effects make plant based preparations the main key player of all available therapies. If there is a longterm remedy for diabetes, it must lie in natures pharmacy of putative antidiabetic agents from plants. Medicinal plants with potential antidiabetic activity and their assessment. Bnouham m, ziyyat a, mekhfi h, tahri a, legssyer a.
Shamim hossain, naim hassan, biplab kumar dash, md. It is one of the medicinal plants used in tradition indian medicine as a treatment for diabetes, but little scientific documentation supports its anti diabetic action. Singab and fadia s youssef and mohamed l ashour, year 2014. Singab an, youssef fs, ashour ml 2014 medicinal plants with potential antidiabetic activity and their assessment. A majority of the plant species was tested for antidiabetic activity. Antidiabetic potential of two medicinal plants used in.
Bmc complementary and alternative medicine diabetes mellitus is a metabolic disorder which is rising globally in rich and developing countries. The bioactive compounds of medicinal plants are used as anti diabetic, chemotherapeutic, anti inflammatory, anti arthritic agents where no satisfactory cure is present in modern medicines tanko et al. Antidiabetic activity medicinal plant aegle marmelos. The antidiabetic activity performed in plant is often due to. An acute oral toxicity study was performed as per oecd guidelines 423. In vitro antiglycation activity of some medicinal plants used in diabetes mellitus. Pdf electrochemical measurement of antidiabetic potential. Diabetes mellitus and natures pharmacy of putative. An overview on antidiabetic medicinal plants having insulin. Antidiabetic plants, diabetes, hypoglycaemic activity, medicinal plants, oxidative stress introduction the world health organization who defines diabetes mellitus dm as a degenerative and chronic disease that occurs when the pancreas does not produce enough insulin, or when the body cannot effectively use insulin 1. Metformin, for example, is an oral hypoglycemic agent isolated from medicinal plant galega officinalis that was used historically in medieval europe for the treatment of diabetes 11. Evaluation of in vitro anti diabetic activity of selected. Antidiabetic potential of medicinal plants and their active.
Introduction antidiabetic drugs treat diabetes mellitus by lowering glucose levels in the blood. Diabetes mellitus, medicinal plants, antidiabetic, hypoglycemic, antihyperglycemic. Medicinal plants are cheaper, more accessible to the most of the population in the world. Antidiabetic potential of some less commonly used plants in. Determination of in vitro antidiabetic effects of zingiber. Various antidiabetic plants have been worked out and one. As the extract showed potential activity against staphylococcus aureus ncim 5021. Promising antidiabetic drugs, medicinal plants and herbs. Antidiabetic activity of artemisia amygdalina decne in. Plant species with antidiabetic properties plantbased medicinal products have been known to man since ancient times, subbulakshmi and naik, 2001.
Antidiabetic medicinal plants research papers academia. Ashrafuzzaman sapon, monokesh kumer sen abstract in the last few years, there has been an exponential growth in the field of herbal medicine and gaining. Mohamed b, abderrahim z, hassane m, abdelhafid t, abdelkhaleq l. The antidiabetic activity was found to be effective against escherichia coli, pseudomonas putida, staphylococcus aureus and klebsiella pneumonia. Medicinal plants are cheaper, more accessible to the. Undoubtedly, medicinal plants will increasingly become part of the antidiabetic drug mix. Open access international journal of pharmacology issn 18117775 doi. The scientists at isfahan university, isfahan, iran evaluated the anti diabetic effect of ethanolic walnut leaf extract. Essential oils of four species used in traditional medicine in bani matar district in yemen, family lamiaceae were assessed chemically and biologically for their antidiabetic activity. Antidiabetic activity of medicinal plants diabetestalk. Antidiabetic activity of ethanolic extract of hydnocarpus.
Doses which have antidiabetic activity were reported as 50 and 100 mgkg body weight18. Approach to phytochemistry and mechaniasm of action of plants. The present study was designed to investigate the glucose uptake of antidiabetic activity crude nhexane,ethanol, methanol and aqueous leaf extracts of cardiospermum halicacabum. Momordica charantia is a flowering vine in the family cucurbitaceae. By acute toxic class method swiss albino mice of female sex weighing 2025gms were used for the study. Moderate antimicrobial activity was recorded against li ncim 2065, salmonella typhi and. Neelesh malviya, sanjay jain, et all 2014 has examined.
The present study was designed to investigate the glucose uptake of antidiabetic activity crude nhexane,ethanol, methanol and aqueous leaf. The efficiency of these medicinal plants may regulate the diabetic metabolic. Approach to phytochemistry and mechaniasm of action of. When gymnema leaf extract is administered to a diabetic patient, there is stimulation of the pancreas by virtue of which there is an increase in insulin release 14.
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